HALO® Elevate – Taking Separations to a Higher Level
Built upon proven Fused-Core® particle technology for speed and efficiency, the HALO® Elevate C18 incorporates surface modified organo-silane technology for alkaline resistance resulting in excellent stability in high pH/high temperature environments.
With a wide operational use range of pH 2-12, HALO® Elevate allows for robust method development and improved separations for basic compounds that may present problems at lower pH, for poor peaks shapes, inadequate retention, or limited load tolerance. Ideal for use with high pH mobile phases, HALO® Elevate protects against degradation of the silica particle which is demonstrated by aggressive stability tests at elevated temperatures.
Available as a 120 Å pore size, these columns are optimized to deliver performance for high pH, to be flexible enough to work the full range of operating conditions to dial in separation selectivity for acids, bases, neutrals and zwitterions. The underlying HALO® Fused Core® technology is incorporated for separation speed and chromatographic efficiency to provide the quality HALO® has been known to exhibit.
Delivering More Performance
Excellent Stability for High pH Environments
Reliability of Proven Fused-Core® Technology for Highest Efficiencies
Enables Wide Operational Use Range for Robust Method Development
HALO® Advantage!
PEAK IDENTITIES
- Uracil
- Acenaphthene
- Amitriptyline
Excellent Stability of HALO® Elevate C18 Over 500 Injections
Run Conditions: pH 10 @ 60°C
(>20,000 column volumes, 42 hours of run time)
*see toss sheet for full test conditions
PEAK IDENTITIES
- Related Compound F & G
- Related Compound B
- Related Compound E
- Related Compound A
- Impurity B
- Omeprazole
- Impurity H
- N’-Methyl Omeprazole
- Impurity C
Modernized Omeprazole Separation on HALO® Elevate C18
Run Conditions: pH 10.7, @ 60 °C
*see toss sheet for full test conditions
PEAK IDENTITIES
- Butyl Paraben (neutral)
- Doxylamine (base)
- Chlorpheniramine (base)
- Doxepin (base)
- Amitriptyline (base)
- Trimipramine (base)
Lot to Lot Study of HALO® Elevate C18
Run Conditions: pH 10 @ 60°C
The average %RSD across all of the compounds was < 0.6%.
*see toss sheet for full test conditions
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Featured Documents
taking advantage of fused-core® technology
Visit our solutions pages to learn more about the best uses and benefits of Fused-Core® Technology.
From an ultra-fast separation of a few compounds to a more complex natural product sample containing hundreds of analytes, HALO® columns offer an optimized solution for separation challenges.
Biopharmaceuticals are inherently more complex than small molecules. HALO® BioClass columns have been specifically designed to accomplish these bio-separation goals with a simplified and more effective solution.
Solutions for other persistent, high environmental-impact contamination agents such as pesticides, mycotoxins, herbicides, and more all based upon HALO’s 15 years of innovative and trusted technology.