新面世的HALO® PCS固定相 – 卓越的性能
HALO® PCS 色谱柱产品，是基于成熟的、能够大大提高分析速度和效率的核壳（Fused-Core®）型硅胶基础上研发出来的。与标准 C18 和Phenyl-Hexyl色谱柱相比，这个固定相的硅胶表面带正电，从而保证了碱性分子的峰形得以充分改善。
HALO® PCS非常适用于低离子强度的流动相，在此条件下，即使是较高的载量仍然能够保持很好的峰对称性，而且，从选择性方面来说，可以作为C18和Phenyl-Hexyl键合相的替代品。
提供 90 Å 和 160 Å 孔径的固定相，可以分别用于小分子和多肽分析。
经过优化，这些色谱柱能够保证稳定重现的、高柱效的LC和LCMS的分离。
满足更好的分析要求
碱性化合物分析具有完美的峰形和更高的上载量
与UHPLC 和 LCMS 兼容
基于核壳（Fused-Core®）型硅胶，可实现快速、高效和可靠的分析分离
新型固定相的选择
- 2.7 µm particle size, 90 Å pore size optimized for small molecules
- Alternate L1 Selectivity
- Basic pharmaceutical drugs, environmental contaminants, drugs of abuse
- 2.7 µm particle size, 90 Å pore size optimized for small molecules
- Alternate L11 Selectivity
- Basic pharmaceutical drugs, environmental contaminants, drugs of abuse
- 2.7 um particle size, 160 Å pore size optimized for peptide separations
- Alternate L1 Selectivity
- Peptide mapping and detection, impurity analysis
HALO® Advantage!
- A mix of four antidepressants is separated using the HALO 90 Å PCS C18 column.
- The positive charged surface (PCS) stationary phase is ideal for basic analytes when using low ionic strength mobile phases such as formic acid.
- Improved tailing factor and efficiency are observed when compared to a traditional (uncharged) C18 stationary phase.
Separation Using HALO® PCS C18 Compared to C18
*see brochure for full test conditions
Panel of Antidepressants Screened with 900 Injections
Demonstrating the Excellent Stability of HALO® PCS C18
*see brochure for full test conditions
- A HALO® Peptide PCS C18 outperforms a standard peptide C18 column under formic acid conditions due to its positive charge surface, allowing for improved peak shape and resolution for peptides.
- HALO Peptide also allows for a higher sample load on column for basic analytes and could potentially help pull apart closely retained impurities as seen in the graphs.
Peptide Loading Studies
*see brochure for full test conditions
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taking advantage of fused-core® technology
Visit our solutions pages to learn more about the best uses and benefits of Fused-Core® Technology.
From an ultra-fast separation of a few compounds to a more complex natural product sample containing hundreds of analytes, HALO® columns offer an optimized solution for separation challenges.
Biopharmaceuticals are inherently more complex than small molecules. HALO® BioClass columns have been specifically designed to accomplish these bio-separation goals with a simplified and more effective solution.
Solutions for other persistent, high environmental-impact contamination agents such as pesticides, mycotoxins, herbicides, and more all based upon HALO’s 15 years of innovative and trusted technology.